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It has been proven that glutamate-induced excitatory toxicity can bring damage to nerve cells. Previous studies indicate that glutamate excitotoxicity-associated neuron damage play an important role in the pathogenesis of a number of nervous system diseases, and estrogen can protect neurons from glutamate excitotoxicity-associated neuron damage, which may be mediated by estrogen receptor. This paper reviews the latest progress regarding the protective effects of estrogen and its receptors against glutamate-induced neuron damage.
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Objective To explore the changes serum S-100? in children with acute carbon monoxide poisoning and its clinical significance.Methods The levels of serum S-100? of 28 children with acute carbon monoxide poisoning and those of 20 healthy children were mea-sured by enzyme-linked immunosorbent assay.Results The serum S-100? levels of the study group and control group were(0.517?0.346)and(0.037?0.014)?g/L respectively,there was significant difference between two groups(t=6.197 P
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0.05),but the latter was superior to the former in extinction of exanthem.4.B_(19)-DNA clearance of hormone group was 25.0%,that of gamma globulin group was 81.82%,and there was significant difference between 2 groups(P
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Objective To explore the changes of S - 100? protein in cerebrospinal fluid and serum of children with viral encephalitis and its clinical significance. Methods The levels of S - 100? protein of cerebrospinal fluid and serum of 36 children with viral encephalitis and 20 lumbar anesthesia children without central nervous system diseases were measured by enzyme - linked immunosor bent assay. Differences in the levels of cerebrospinal fluid and serum S-100? protein between children with and without coma, with and without convulsion, with and without sequelae in the case group were compared. Results S-100? protein levels of cerebrospinal fluid in the case group and control group were (0.641?0.390) and (0.037 ? 0.014) ?g/L( P
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Objective To discuss the MRI features of sophorae subprostrate intoxication.Methods Four cases with sophorae subprostrate intoxication underwent conventional MRI and diffusion-weighted imaging(DWI)with a 1.5 T MR system.Results In four cases,all cerebellar dentate nuclei showed symmetric patchy hyper-intensity on T_2 weighted images and iso-intensity on diffusion-weighted images as well as hyper-intensity on ADC maps.The bilateral dorsum of the brain stem and thalamus were involved in one ease.Symmetric long T_1 and T_2 signals and high DWI signals with low ADC values in bilateral basal ganglia area were demonstrated in one case with severe symptoms.After treatment,repeated MR images in two cases showed the abnormal signals of dentate nucleus disappeared,and the lesions of basal ganglia area in one case tended to be cystie with longer T_1 and T_2 signals and low DWI signals.Conclusion It is specific for intoxication of sophorae subprostrate to affect the dentate nuclei and lentiform nuclei.MRI and DWI is helpful for the early diagnosis,differential diagnosis and prognosis evaluation of this disease.